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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 8 pot

A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 8 pot

Ngày tải lên : 14/08/2014, 07:20
... tell a story in as clear and concise a fashion as possible Only the tabular material and graphs associated with the main theme should be incorporated directly in the analysis section All the other ... between the actual adverse event and the end of the calendar quarter in which it was included in an AERS data release The sharp periodic peaks represent dates that were coded as “January 1,” rather ... can resolve all the above issues in the negative, then the analysis is straightforward Otherwise, we need to subdivide the sample into strata based on the differentiating factors and perform a...
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Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx

Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx

Ngày tải lên : 19/02/2014, 07:20
... A novel tyrosinase from Rastonia solanacearum ´ D Hernandez-Romero et al A B C particular catechol to o-dopaquinone is also called dopa oxidase (DO) activity On the other hand, laccases ... structure data 266 ´ D Hernandez-Romero et al The only data so far available are for sweet potato (Ipomoea batata) catechol oxidase [26] The catalytic copper center is accommodated in a central four-helix ... tyrosinase from Rastonia solanacearum environmental pH, may also affect the expression of the most appropriate enzyme Apart from the physiological roles and environmental advantages of having several...
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PRACTICAL TAXIDERMY A MANUAL OF INSTRUCTION TO THE AMATEUR IN COLLECTING, PRESERVING, AND SETTING UP NATURAL HISTORY SPECIMENS OF ALL KINDS doc

PRACTICAL TAXIDERMY A MANUAL OF INSTRUCTION TO THE AMATEUR IN COLLECTING, PRESERVING, AND SETTING UP NATURAL HISTORY SPECIMENS OF ALL KINDS doc

Ngày tải lên : 06/03/2014, 13:20
... touching the chin, and the hands by the sides of the face It is quite dry and hard; the features are distorted, but nearly perfect, and the hair has fallen off The Peruvian mummies not appear to have ... others waited round and were caught afterwards The well-known and easily imitated call of the bullfinch at this season of the year (autumn) appears to have a greater attraction — for what reason ... dreamed of fifty years ago — and also correctly model the heads and limbs of animals, we still hold our own, and are as far advanced in taxidermy as any other nation CHAPTER II DECOYING AND TRAPPING...
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A BOATER’S GUIDE TO THE FEDERAL REQUIREMENTS FOR RECREATIONAL BOATS AND SAFETY TIPS potx

A BOATER’S GUIDE TO THE FEDERAL REQUIREMENTS FOR RECREATIONAL BOATS AND SAFETY TIPS potx

Ngày tải lên : 17/03/2014, 14:20
... Distress Flag Pistol-launched and hand-held parachute flares and meteors have many characteristics of a firearm and must be handled with extreme caution In some states and Canada they may be considered a firearm and ... Port -to- Port Passing (preferred) Navigation buoys and beacons are placed along coastal and navigable waters as guides to mark safe water and hidden dangers, as well as to assist boat operators in determining their position in relation to land ... Atmospheric Administration’s National Ocean Service (NOS) produces a NN N variety of nautical charts and related products Nautical charts can vary in scale and format Chart scale refers to a measurement of an area, not the distance A chart covering a relatively large area is called a “small scale”...
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A Bayesian network approach to the database search problem in criminal proceedings docx

A Bayesian network approach to the database search problem in criminal proceedings docx

Ngày tải lên : 23/03/2014, 12:20
... face a charge based on a ‘database hit’ For these reasons, questions that emanate from the use made of matches derived from database searches, as well as the assessment of their evidential value, ... individuals not correspond to the profile of the crime stain This variable does depend on the size of the database as well as the rarity of the analytical characteristic The matching suspect and the ... debate ‘What is the strength of the evidence against a suspect who is found as a result of the search in a database?’ This practical question, also sometimes referred to as the database search...
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princeton university press religious experience reconsidered a building-block approach to the study of religion and other special things oct 2009

princeton university press religious experience reconsidered a building-block approach to the study of religion and other special things oct 2009

Ngày tải lên : 11/06/2014, 12:43
... mystical, magical, and so forth within larger processes of meaning making and valuation (singularization), we are better able to analyze the contestations over the meaning and value of particular ... people set apart and the way they respond to them •   hings are always set apart relative to other things in a class SetT ting something apart in this way marks it as special; we can refer to this ... my doctoral seminar— Robert Borneman, Jared Lindahl, Andrew Mansfield, Andrea Neuhoff, Albert Silva, and Kristy Slominski—hammered away at the first draft of the manuscript, especially the first...
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Giáo án Tiếng Anh lớp 8: Unit 6 The young pioneers club Lesson 2 : Speak A/ Aims and Objectives : By the end of the lesson , pps

Giáo án Tiếng Anh lớp 8: Unit 6 The young pioneers club Lesson 2 : Speak A/ Aims and Objectives : By the end of the lesson , pps

Ngày tải lên : 08/08/2014, 02:22
... make the dialogue and move around the class and help Ss - Call on some Ss to practice the dialogue in front of the class V / Homework : Learn by heart the expressions to offer assistance and favor ... chorally and then individually all the phrases in the chart Closed pairs III / Practice : Ask Ss to work in pairs to practice the dialogues - Call on some pairs to practice in front of class - Correct ... pronunciation if any Use appropriate phrases to make similar dialogues about some of the following situations with a partner Practice the - Have Ss work in pairs dialogues in front - Call on...
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cáo khoa học: " Barriers and facilitators to the dissemination of DECISION+, a continuing medical education program for optimizing decisions about antibiotics for acute respiratory infections in primary care: A study protocol" potx

cáo khoa học: " Barriers and facilitators to the dissemination of DECISION+, a continuing medical education program for optimizing decisions about antibiotics for acute respiratory infections in primary care: A study protocol" potx

Ngày tải lên : 10/08/2014, 10:23
... developing and monitoring interventions tailored to those barriers and facilitators; and evaluating outcomes Assessing barriers and facilitators to practitioners’ use of research requires investigating ... 4E9, Canada Authors’ contributions ASA, FL and ML conceived the study and validated the methods ASA wrote the first draft and revised the protocol FL, ML, AG, JG each reviewed and modified various ... was provided by KT Canada, a research network funded by a Canadian Institutes of Health Research (CIHR) grant (Knowledge Translation Canada: A National Research Network 200710CRI-179929-CRI-ADYP-112841)...
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Báo cáo y học: "Lateral rectus muscle disinsertion and reattachment to the lateral orbital wall in exotropic Duane syndrome: a case report " pdf

Báo cáo y học: "Lateral rectus muscle disinsertion and reattachment to the lateral orbital wall in exotropic Duane syndrome: a case report " pdf

Ngày tải lên : 11/08/2014, 21:22
... goal is to correct the deviation and head turn and ameliorate as much of the anomalous eye movement as possible [5] Surgical treatment frequently requires a large recession of anomalous lateral ... recession far back from the equator and suturing on the globe [5] In a severe form of lateral rectus cocontraction, a large recession cannot eliminate the action of the anomalous firing lateral rectus ... inactivation could eliminate the anomalous lateral rectus muscle; therefore, the upshoot and globe retraction were substantially decreased Rao VB, Helveston EM, Sahare P: Treatment of upshoot and...
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báo cáo khoa học: " The YlmG protein has a conserved function related to the distribution of nucleoids in chloroplasts and cyanobacteria" pdf

báo cáo khoa học: " The YlmG protein has a conserved function related to the distribution of nucleoids in chloroplasts and cyanobacteria" pdf

Ngày tải lên : 12/08/2014, 03:21
... 5'-GACAGGTTCAGGTCATAGAAG-3' for At5g21920, 5'-TATCTGAACACTCCGTTGACGGTA-3' and 5'-CAAAGATA AACGGAATACGATC-3' for At4g27990, 5'-GCAATGGGAAGCAGTGGTGG-3' and 5'-GGGAGAAGAGACGGGTTTCG-3' for GAPDH, and ... identify the inserted 35S-cDNA in the FOX lines, the insertion was amplified by PCR using primers 5'GTACGTATTTTTACAACAATTACCAACAAC-3' and 5'-GGATTCAATCTTAAGAAACTTTATTGCCAA-3', and then sequenced by a ... (Takara) with oligo(dT)15 primer PCR was performed by using primers 5'-CACCGAGAAGTCAACAGCTCGGTCATCGAC-3' and 5'-TCAAGTCTTCCAATTTCTACCCAGTGCTGC-3' for AtYLMG1-1, 5'CCTCAACATATATAACACCATC-3' and...
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Báo cáo y học: " A validity-driven approach to the understanding of the personal and societal burden of low back pain: development of a conceptual and measurement model" doc

Báo cáo y học: " A validity-driven approach to the understanding of the personal and societal burden of low back pain: development of a conceptual and measurement model" doc

Ngày tải lên : 12/08/2014, 18:20
... separated the patient and professional groups in order to facilitate frank discussion, and broad and rapid brainstorming To maximize the richness and depth of the data obtained, we used a nominal ... Education Standards for educational and psychological testing Washington, DC: American Educational Research Association; 1999 30 American Psychological Association., American Educational Research ... Pedhazur et al [28], and the standards for educational and psychological testing, (henceforth the Standards’), developed jointly by the American Educational Research Association, the American Psychological...
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Báo cáo y học: " The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3'''',3''''-"</h1> <p style="font-size:11px;margin-bottom:3px;">Chia sẻ: <a href="http://tailie

Báo cáo y học: " The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3'''',3''''-"</h1> <p style="font-size:11px;margin-bottom:3px;">Chia sẻ: <a href="http://tailie

Ngày tải lên : 13/08/2014, 13:20
... lysed and the Gag proteins immunoprecipitated using CA-specific monoclonal antibodies, and radioactive proteins in the immunoprecipitates analyzed by SDS-PAGE and autoradiography Panel A: Analysis ... primer) The PCR product was digested with SpeI and ApaI and used to replace the corresponding fragment in pNL4-3 Primers used to produce SIVm2 were: GAAGGCTCGAGTACTGGCAGAAGCCATGAAAGAG (sense) and ... A/ G-conjugated agarose beads (Santa Cruz Biotechnology), and the labeled proteins separated by SDS-PAGE and visualized by autoradiography Radioactivity in protein bands was quantified using a Fuji...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 1 ppsx

A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 1 ppsx

Ngày tải lên : 14/08/2014, 07:20
... you’ll have taken the first steps toward obtaining transnational approvals at no increase in costs The United States, Japan, and the Electronic data capture cuts European Union have already costs and ... CONTENTS Preparing the Common Technical Document 241 Data Management 241 Data Entry and Data Management 242 Small-Scale Clinical Studies 242 Clinical Database Managers 242 Data Analysis 243 Utilities ... Further Information 187 15 Data Analysis 189 Report Coverage 189 Understanding Data 190 Categories 190 Metric Data 192 Statistical Analysis 194 Categorical Data 196 Ordinal Data 197 Metric Data...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 2 pps

A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 2 pps

Ngày tải lên : 14/08/2014, 07:20
... choosing the appropriate software for data entry, data management, and statistical analysis is normally divided among the lead software engineer, the data manager, and the statistician (subject, ... and analyze the data you collect DO Steps C–F can be executed in parallel C Obtain Regulatory Agency Approval for the Trials Obtaining regulatory agency approval can be as simple as submitting a ... member of the programming team, but she must possess a general knowledge of both data entry and data management software and be able to prepare and maintain a flow or Gant chart for the development...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 3 pps

A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 3 pps

Ngày tải lên : 14/08/2014, 07:20
... 58 PART I PLAN trials are completed and the data analyzed, there is no rational basis for other than a random assignment Warning: An investigator who has strong feelings for or against a particular ... possible to reach a final conclusion (at least one acceptable to the regulatory agency) until all the data are in, there may be sufficient evidence at an earlier stage to launch a second broader set ... justify the expenditure And you’ll still be obligated to track down each patient once all the data are in and analyzed in order for their physicians to give them a final briefing By having all trials...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 4 potx

A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 4 potx

Ngày tải lên : 14/08/2014, 07:20
... crossover trials are contemplated, a pharmacokineticist is an essential addition to the design team To maintain the validity of a fractional factorial design one has to be able to assume that the effect ... Treatment A is the same at all levels of the cofactor and in all subgroups Again, these assumptions are seldom realized in practice and represent major drawbacks for the methodology But the main ... was the lack of commercially available software with which to design the experiment and perform the analysis Fortunately, S+SeqTrial and EAST are now available (see Appendix) TAKING COST INTO...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 5 potx

A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 5 potx

Ngày tải lên : 14/08/2014, 07:20
... your final report and an electronic copy of your database and the programs you’re used to retrieve and analyze the data In the United States, the latter is termed an e-sub or CANDA (Computer-Aided ... monies available downstream) Obtain new staff to help with clinical trial (this motivator could backfire as the physician begins to think of the staff as his own and wants to assign them to other tasks) ... to the data extraction and analyses programs so that the results may be independently validated Almost all the statistical analyses you perform will require you to first group the data For example,...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 6 pdf

A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 6 pdf

Ngày tải lên : 14/08/2014, 07:20
... issues are discussed: Choice of data management software and the options available to you Transfer of data from data entry to data storage and from data storage to your report generating and statistical ... languages for data entry, data management, and data analysis is normally divided among the lead developer, the data manager, and the statistician The project manager may be called upon to resolve ... problems of storage and retrieval Relational Database Model A relational database appears to stores all its data inside tables Each table consists of a set of rows and columns similar (from the user’s...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 7 pot

A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 7 pot

Ngày tải lên : 14/08/2014, 07:20
... Data entry software Transfer of data from the investigator to central storage Transfer of samples from investigator to external laboratory and of data from external laboratory to central storage ... three ways: Enter directly at each physician’s computer Transfer the data automatically at day’s end via telephone to the central database Copy the data each day to a CD; at the end of the week the ... your approval Thereafter, all decisions as to access to the data will be yours alone Maintaining an Audit Trail To avoid even the appearance of fraud, and to satisfy government regulations, all...
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